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Doxorubici hydrochlorideDetails
Chemical Name:Doxorubici hydrochloride
CAS No.:25316-40-9
Molecular Formula: C27H30ClNO11
Molecular Weight:579.98
Appearance:Orange-Red Crystalline powder
Doxorubici hydrochlorideTypical Properties
| Items | Requirements | Results |
| Description | Orange-Red Crystalline powder,Hygroscopic,NoVisible Evidence Of Contamination By ForeignMaterial | Pass |
| Assay | 98.0~102.0% | 99.52% |
| Solubility | Solubility in water,Slightly Solubility in methano;Practically insolubility in Chlorofor and DiethylEther | Pass |
| Identification | The retention time of the Doxorubici peak in thechromatogram of the test preparation corresponds tothat in the chromatogram of the standard preparation | Pass |
| PH | 4.0~5.5 | 5.08 |
| Moisture | <4.0% | 1.33% |
| Chromatographic purity | Total impurities:<2.0% | <0.32% |
| Solvent Residues | Aceton<0.5%; Aceton Alcohol<2.5% | 0.11%;0.39% |
Doxorubici hydrochlorideUsage
1. Doxorubici is an anti-tumor antibiotic that inhibits the synthesis of RNA and DNA. It has the strongest inhibitory effect on RNA, has a broad anti-tumor spectrum, and has a role in various tumors. It is a non-specific drug of the cycle. Tumor cells of various growth cycles have a killing effect
2. Anti-tumor antibiotics, which have the effect of doxorubici in cardiac mitochondrial DNA. Inhibitors of reverse transcriptase and RNA polymerase, immunosuppressive agents; can be inserted into DNA strands. Clinically, it is a cancer chemotherapy agent, mainly used for acute and chronic leukemia and malignant lymphoma.
3. Adriamycin hydrochloride is an antibiotic anticancer drug that can penetrate into cells and cross the DNA of tumor cells, bind, inhibit DNA replication, block the action of RNA polymerase, inhibit the synthesis of RNA; its cytotoxicity and freedom Base formation, associated with tumor cell membrane binding and fast cell membrane; widely used in cell culture or rat kidney disease, myocardial ischemia and other modeling materials; used to inhibit macromolecular biosynthesis
4. For the treatment of acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin's disease and non-Hodgkin's lymphoma, breast cancer, lung cancer, ovarian cancer
Doxorubici hydrochloridePackaging and Shipping
Packing: Bag, Net weight: 1kg per Bag
Doxorubici hydrochlorideStorage
The warehouse is ventilated and dryat low temperature; it is stored separately fromfood materials.
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