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Chemical Name: Phosphatidylserine/ PS
CAS No.: 51446-62-9
Molecular Formula: C42H82NO10P
Molecular weight: 792.081
Appearance: Fine yellow powder
Assay: 20% 50% 70% powder
Phosphatidylserine Typical Properties
| Items | Standard |
| Color and Appearance | Fine yellow powder |
| Odor | Characteristic |
| Taste | Characteristic |
| Identification | Same with standard |
| Phosphatidyl serine | ≥20% |
| Phosphatidyl
|
≤16% |
| Phosphatidylinositol | ≤12% |
| Phosphatidylcholine | ≤20% |
| Peroxide value | ≤10meq/KG |
| Loss on Drying | ≤5.0% |
| Heavy metals | ≤10PPM |
| Arsenic | ≤1PPM |
| Lead | ≤3PPM |
| Total plate count | ≤10000cfu/G |
| Total yeast mold | ≤1000cfu/G |
| E.coli. | Negative |
| Salmonella | Negative |
| Staphylococcus | Negative |
Phosphatidylserine Physical and chemical properties
Pure PS is a white waxy solid, soluble in most non-polar solvents containing a small amount of water and insoluble in anhydrous acetone. It can be extracted from tissues and cells by chloroform-methanol extraction method. When PS dissolves in water, most insoluble lipids form micro-clusters except for a few true solutions. At pH 7, PS has two negative charges and one positive charge, leaving a net negative charge. Metal salts of fatty acids are hydrolyzed by weak alkali, and the rest is not hydrolyzed. Fatty acids, serine, and glycerol phosphate are produced by strong alkali hydrolysis. PS exposed to air is easy to be oxidized, and the color gradually deepens, from white to yellow, and finally to black. The natural PS is almost free from alcohol. The saturated PS and alcohol form a staggered chain gel. The interaction of two palmityl phosphatidylserine with 5% alcohol at room temperature induces the formation of the regular gel.
The structure of PS consists of three parts:
the head of the hydrophilic Glycerol Skeleton and the tail of two long hydrocarbon chains. The head is composed of three groups, serine residue, and phosphoric acid residue, and the other two light groups of C-3 glycerol are connected with fatty acid to form the tail respectively. Compared with C-1 fatty acids, C-2 fatty acids have longer carbon chains and more unsaturated bonds. Phosphatidylphthaleine serine (PS) refers to a group of compounds, not a single component, which is due to the great changes in the ethyl phthalide residues of products extracted from different sources. PS is amphiphilic, that is, it is hydrophilic and lipophilic. Its structure determines its unique properties. The head with a negative charge is hydrophilic (or water-soluble), and the tail composed of fatty acids is lipophilic (or fat-soluble).
Pharmacokinetics:
PS extracted from the bovine cerebral cortex (BC-PS) was absorbed slowly by oral administration. The blood concentration of PS increased within 4 hours and reached its peak after 24 hours. The maximum absorption peak of 14C After intravenous administration of BC-PS, plasma clearance was very fast, showing a biphasic curve. The half-life of the first phase distribution curve is 5 minutes, which mainly reflects the uptake of the drug by the liver. The half-life of the second phase distribution curve is 15 minutes, which may be related to the action of blood cells. In addition to the liver, lung and spleen are also important for the uptake of BC-PS. The drug dosage in the brain is less, mainly concentrated in the cortex, thalamus, and hippocampus. Some BC-PS in human blood can be converted into phosphatidyl phthalein by de-pressing or hemolytic PS by de-phthalide group, and serine can also be removed. The latter enters the amino acid metabolic pathway. However, liposoluble phosphatidic acid metabolites still play a major role in plasma, mainly in prototype drugs. The metabolic process of BC-PS in the liver and brain is similar to that in blood. Regardless of the mode of administration, BC-PS is excreted mainly through the intestine, followed by the kidney. Liposoluble metabolites and prototype drugs are mainly excretion through the intestine, while water-soluble metabolites are mainly excretion through the kidney.
Phosphatidylserine Packaging and Shipping
Packing: 25Kg/drum
Delivery: Delivery within 3-5working days
Phosphatidylserine Storage
Avoiding light and drying.
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